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CMM 250 Core Course Winter 2019


Instructor: Karl Willert ( 858-822-3235

Administrative Contact: Marci Murray ( 858-534-8510


Winter 2019, January 8 - March 14, 2019

Tuesdays and Thursdays 8:30 – 10:30 a.m.

The Sanford Consortium for Regenerative Medicine, Room 3803

This course provides the latest information in stem cell biology, medicine, and ethics. Faculty members from UCSD, The Sanford Burnham Preby's Medical Discovery Institute, The Salk Institute, La Jolla Allergy & Immunology, and The Scripps Research Institute will give 1-hour lectures on the basic concepts of embryonic and adult stem cells. In addition, once per week students will present scientific papers that cover some of the recent findings in these rapidly advancing fields of stem cell research.
Scientific lectures
Faculty speakers will present basic, translational and clinical research findings involving stem cells in human and model systems. Topics will include what is known about various stem cell populations; the identification, purification and properties of stem cells; possible and actual uses of stem cells in animal models of relevant diseases; possible and actual uses in clinical application to an organ system or disease state. Active participation is encouraged and will be a main criterion for grading. 

Journal Club
All students will present one or two papers during the course. On the first day of class the instructor will assign presentation dates. Students will select one original research paper relevant to topics covered during the course. For each paper, the presenter is expected to provide an introduction, background and significance of the topic. To ensure active participation in the journal club, the presenter will call on the other students at random to explain a given figure.

Attendance is mandatory. You must sign in every week on the sheet provided. One excused absence will be allowed per quarter.
Faculty lecturers will present topics in a manner that encourages participation by the students. Questions and comments are highly encouraged and spontaneous contributions will be a major criterion for grading.
Each student will present at least one paper of their choice during the course. Introductory presentations should be relatively brief (10-15 minutes), thoroughly prepared and clearly delivered. In preparing these presentation, it may helpful to incorporate recent reviews on the topic of the paper. Students are strongly encouraged to use Powerpoint, Keynote, or PDFs to assist in the clarity and concision of the presentation. The main job of the presenter is to help the class gain a clear understanding of the conceptual context, purpose and significance of each paper. The presenter is responsible for importing each figure (including supplemental figures from journal websites, if needed) into Powerpoint for presentation by randomly selected students. The instructor will be available for consultation during the preparation of presentation to offer guidance and help on the presentation content.


Course Syllabus CMM 250 WI19

9:30 am - 10:30 am


Week 1
January 8, 2019 Tuesday Course Introduction “Pluripotent stem cells” Karl Willert, Ph.D.

“HSC Development” David Traver, Ph.D.

January 10, 2019 Thursday

“Wnt signaling in stem cells”

Karl Willert, Ph.D.

Sanford Seminar, Roth Auditorium

Week 2
January 15, 2019 Tuesday

“Endodermal Progenitors and Modeling Diabetes in a Dish”

Maike Sander, M.D.

“Viacyte Clinical Trial Update”

Kevin D’Amour, Ph.D.
January 17, 2019 Thursday

"Genome Engineering: A Primer"

Prashant Mali, Ph.D.

Journal Club #1

Jaimie Mayner
Week 3
January 22, 2019 Tuesday

“Regeneration in planaria”

Ricardo Zayas, Ph.D.

“HSC Maintenance”

Robert Signer, Ph.D.
January 24, 2019 Thursday

“Growing human organs”

Juan Carlos Izpisua Belmonte, Ph.D.
Journal Club #2 Alexander Whitehead Bernadette Chua
Week 4
January 29, 2019 Tuesday “Utilization of Stem Cells in Spinal Cell- Replacement-Based Therapies” Martin Marsala, M.D.

“Generation of functional human brain organoids”

Alysson Muotri, Ph.D.
January 31, 2019 Thursday

“Introduction to Stem Cell Ethics”

Mary Devereaux, Ph.D.

Journal Club #3

Mary Devereaux – Ethics Journal Club
Week 5
February 5, 2019 Tuesday

“Stem cells, gene therapy and cystinosis”

Stephanie Cherqui, Ph.D.

“Building a lung”

Xin Sun, Ph.D.
February 7, 2019 Thursday

“Using Next-Generation Sequencing to Study Cellular Differentiation and Reprogramming” Chris Benner, Ph.D.

Journal Club #4.1

Gabriela Goldberg
Week 6
February 12, 2019 Tuesday

“Spermatogonial Stem Cells”

Miles Wilkinson, Ph.D.

“Trophoblast stem cells and placental development”

Mana Parast, M.D., Ph.D.
February 14, 2019 Thursday

“Immunological Consequences of Cellular Reprogramming Processes"

Gerald Morris, M.D.

Journal Club #4.2

Ryan Geusz
Week 7
February 19, 2019 Tuesday

“Liver and Regeneration”

David Brenner, M.D.

“DNA Modifications and Their Biological Roles”

Anjana Rao, Ph.D.
February 21, 2019 Thursday

“Tissue Engineering”

Adam Engler, Ph.D.
Journal Club #5 Dylan Phan Aileena Nelson
Week 8
February 26, 2019 Tuesday

“Hippo signaling in stem cells”

Kun Liang Guan, Ph.D.

“Bio-responsive nano-materials”

Ester Kwon, Ph.D.
February 28, 2019 Thursday

“Cardiac Stem Cells”

Farah Sheikh, Ph.D.
Journal Club #6 Daniella McDonald Kyle Ford
Week 9
March 5, 2019 Tuesday

“Modeling eye diseases”

Karl Wahlin, Ph.D.

“Epidermal stem cells”

George Sen, Ph.D.
March 7, 2019 Thursday

“Cancer Immunotherapies”

Dan Kaufman, M.D., Ph.D.
Journal Club #7 Miranda Diaz Amir Dailamy
Week 10
March 12, 2019 Tuesday

“Cancer and cancer stem cells”

Catriona Jamieson, M.D., Ph.D.

“Brain cancer”

Jeremy Rich, M.D., Ph.D.
March 14, 2019 Thursday

“Imaging Technologies”

Eric Ahrens, Ph.D.

Sanford Seminar, Roth Auditorium

Sally Temple (Neural Stem Cell Institute)