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Stem Cell Science with Alysson Muotri Episodes 

 

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  • On Beyond: 3D Printing and Stem Cells, Top Science Discovery of 2019, Robotics

    On Beyond: 3D Printing and Stem Cells, Top Science Discovery of 2019, Robotics

    One of the top ten science achievements of 2019, Using 3D printing to connect stem-cell derived brain and eye models, and a look at developments in robotics. (#35687)
  • On Beyond: Fighting Leukemia, Natural Reserves, Studying Climate Change Through Surfing

    On Beyond: Fighting Leukemia, Natural Reserves, Studying Climate Change Through Surfing

    How Zebrafish help in the search to produce blood stem cells, California's Alpha Clinics, the extraordinary UC Natural Reserve system, and developing an innovative crowd-sourced network of remote sensors to track change in the ocean - on surfboards. (#35686)
  • On Beyond: Our Social Brain and Autism, Informal Computer Education, Tracking Water

    On Beyond: Our Social Brain and Autism, Informal Computer Education, Tracking Water

    Katerina Semendeferi explores if the potential for conditions like autism is a part of the human mind's extraordinary capacities for intellect and social cognition. A class that trains college students to teach computer science to youngsters in informal space, and how the chemistry of water reveals its history. (#35685)
  • On Beyond: Exploring Brain Development with Stem Cells, Hi-Tech Farming, Building Quadcopters, Lawrence Berkeley Lab, Geysers

    On Beyond: Exploring Brain Development with Stem Cells, Hi-Tech Farming, Building Quadcopters, Lawrence Berkeley Lab, Geysers

    Using brain organoids to understand neural development, learning computer science and engineering by building remotely controlled quadcopters, understanding geysers, high-tech approaches to sustainable agriculture, the work of the Berkeley Laboratories, and a very smart puppy, all on this edition of On Beyond. (#35682)
  • Searching for Autism in our Social Brain

    Searching for Autism in our Social Brain

    Biological anthropologist Katerina Semendeferi describes how the human brain's extraordinary powers of social cognition may predispose only humans to conditions like autism and how she aids the search for the neurophysiology underlying these conditions. (#34330)
  • Discover Magazine Top Ten Science Achievement for 2019: Discovery of Complex Neural Signals in Brain Organoids

    Discover Magazine Top Ten Science Achievement for 2019: Discovery of Complex Neural Signals in Brain Organoids

    A short summary of one of Discover Magazine's top-ten most significant science achievements of 2019 - the discovery of complex neural signals emerging in brain organoids by Alysson Muotri's lab at UC San Diego's Stem Cell Program. (#35392)
  • The Ethics of Brain Organoids with Alysson Muotri, Christof Koch, Patricia Churchland, and Evan Thompson

    The Ethics of Brain Organoids with Alysson Muotri, Christof Koch, Patricia Churchland, and Evan Thompson

    Leading voices in philosophy and neuroscience wrap up a conference on the ethics of research using brain organoids with questions from the audience. Panelists: Christof Koch, Chief Scientist and President of the Allen Institute for Brain Science; Patricia Churchland, Emerita Professor, UC San Diego;
    Evan Thompson, Professor of Philosophy, University of British Columbia; and Alysson Muotri, Director of the UC San Diego Stem Cell program.
    Recorded on 10/04/2019.
    (#35249)
  • The Current Status of Human Brain Organoids Research with Alysson Muotri and Larry Goldstein

    The Current Status of Human Brain Organoids Research with Alysson Muotri and Larry Goldstein

    The study of brain organoids is leading to a better understanding of human development and potential therapies for neurological disorders. Yet when people hear the phrase "brain in a dish" it instantly brings to mind the stuff of science fiction - labs full of sentient brains thinking and plotting. Alysson Muotri explains why these organoids should not called "brains in a dish" and how they are being used to explain human processes previously inaccessible to study. While underscoring scientific value of these organoids, he also raises the question of what ethical questions demand an answer as the technology improves. Recorded on 10/04/2019. (#35245)
  • Using Stem Cells to Research the Brain - Health Matters

    Using Stem Cells to Research the Brain - Health Matters

    Stem Cell research could unlock the mystery of what makes the human brain special. Researcher Alysson Muotri is using stem cells to grow tiny versions of developing human brains in his lab to study everything from autism to the Zika virus. His lab is even looking into how space flight impacts brain development. (#35077)
  • Making Brain Organoids: A Primer

    Making Brain Organoids: A Primer

    Brain organoids, or cortical organoids, hold much promise in finding interventions for neurological conditions, and have already proven useful in understanding the effects of Zika and rare neurological syndromes such as AGS. But how are they made? UC San Diego Stem Cell program project scientist Cleber Trujillo provides a brief overview of how the Muotri lab nurtures pluripotent stem cells into becoming brain organoids. (#34645)

     

  • Beginnings in the Brain: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

    Beginnings in the Brain: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

    A detailed overview of a study conducted by Alysson Muotri's lab at the UC San Diego Stem Cell Program which found complex network signaling developing in human cortical organoids that appear to recapitulate fetal brain development, offering an in-vitro model to study functional development of human neuronal networks. (#34267)
  • 3D Printing Human Tissue with Stem Cells

    3D Printing Human Tissue with Stem Cells

    Bioengineer Shaochen Chen has developed a method of 3D printing live human tissue that could one day be used to heal damaged spinal cords, hearts, and other vital organs. And, because his technology uses stem cells, the transplant tissue can be patient specific. Now, he's using his technique to help researchers Alysson Muotri and Karl Wahlin understand brain and eye development. 

  • Neurobot: Robotics Meets Stem Cells

    Neurobot: Robotics Meets Stem Cells

    High school student Christopher Caligiuri teams up with renowned stem cell researcher Alysson Muotri to build a robot that interprets signals from lab-grown mini-brains. (#34270)

  • Stem Cells and Curing Blindness

    Stem Cells and Curing Blindness

    Scientist Karl Wahlin is hoping to use the tiny retinas he's developed from stem cells to find a cure for blindness. Wahlin has teamed up with UC San Diego Stem Cell Program Director Alysson Muotri, who is using a similar technique to study the brain. Together, they hope to understand how the brain and the eye influence one another's development. (#34273)

  • Building the Brain with Alysson Muotri

    Building the Brain with Alysson Muotri

    Alysson Muotri, Director of the UC San Diego Stem Cell program explores the many ways his and other labs are using brain organoids to understand neurodevelopment. (#34285)

  • When Science Meets Fiction

    When Science Meets Fiction

    The science of stem cells allows us to understand our genome by comparing our own genome to that of our ancient cousins – the Neanderthal. 

    The motion picture William is a story about a Neanderthal living among modern humans. The director of the UC San Diego Stem Cell Program Alysson Muotri was able to visit with the creator and director, Tim Disney, to discuss the real issues explored by this fantasy. (#34804)

  • Neanderthal Among us?

    Neanderthal Among us?

    What makes us human is a question that not only science asks, but all disciplines of mind from philosophy to religion to sociology and ethics, and even to storytelling and the arts. Tim Disney's new movie "William", about a Neanderthal living in the modern world forces us to ask that and many other questions. Director of the UC San Diego Stem Cell Program Alysson Muotri brought together a panel of experts from across a spectrum of disciplines to discuss those issues in a lively and engaging forum with the movie's creator. (#34803)

  • Curing Leukemia: From Zebrafish to Alpha Clinics

    Curing Leukemia: From Zebrafish to Alpha Clinics

    Alysson Muotri explores how discoveries made using tiny Zebrafish will lead to cures for blood diseases like leukemia using stem cells, and how those cures will reach patients through California's network of Alpha Clinics. (#33178)

  • Is Most of your DNA Junk?

    Is Most of your DNA Junk?

    Alysson Muotri and top geneticists Rusty Gage and Miles Wilkinson explore the fact that ninety-nine percent of human DNA doesn't code for anything used by the human body.(#33492)

  • California’s Alpha Clinics: Bringing Science to the Clinic, Creating Cures for You

    California’s Alpha Clinics: Bringing Science to the Clinic, Creating Cures for You

    Alysson Muotri and Catriona Jamieson discuss how cutting-edge stem-cell-based cures will reach patients through California's network of Alpha Clinics. 

  • Reconstructing Brains in the Lab

    Reconstructing Brains in the Lab

    Cerebral organoids, also known as mini-brains, are tridimensional self-organized structures derived from stem cells that resemble the early stages of the human embryonic brain. This new tool allows researchers to explore fundamental neurodevelopmental steps otherwise inaccessible in utero experimentally. Alysson Muotri, UC San Diego Stem Cell Program, explains how mini brains are generated in his lab and how this strategy can create novel therapeutical insights on neurogenetic disorders, such as autism. He also describes the use of mini-brains to explore the uniqueness of the human brain compared to other extinct species, such as the Neanderthals. Limitations and ethical concerns surrounding this exciting technology are also discussed. (#33715)

  • Ethical Boundaries of Research with Human Embryos

    Ethical Boundaries of Research with Human Embryos

    Since stem cells were first cultured from human embryos in 1998, the ethical considerations surrounding this technology have been widely debated, leading to establishment of limits on how this research is conducted and funded. Learn more about these scientific advances, the implications of these discoveries for human health, and consider how ethical norms can best be integrated into research and practice. Recorded on 10/03/2018. (#33712)
  • CARTA

    CARTA

    Alysson Muotri of UC San Diego's Stem Cell Program discusses his work creating cortical organoids from modern humans and Neanderthal to compare the brains of humans and human predecessors. Recorded on 06/01/2018. (#33815)

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